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A Journal on Endocrine System Diseases

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Minerva Endocrinologica 2016 March;41(1):122-37

language: English

Pre-existing diabetes in pregnancy

Suja PADMANABHAN 1, 2, Monica ZEN 3, Vincent LEE 2, 4, 5, Ngai W. CHEUNG 1, 2

1 Department of Diabetes and Endocrinology, Westmead Hospital, Sydney, Australia; 2 School of Medicine, University of Sydney, Sydney, Australia; 3 Department of Obstetrics and Gynecology, Westmead Hospital, Sydney, Australia; 4 Department of Renal Medicine, Westmead Hospital, Sydney, Australia; 5 Centre for Transplant and Renal Research, Westmead Millennium Institute, Sydney, Australia


The incidence of type 1 and type 2 diabetes amongst women of reproductive age is increasing worldwide. Despite recent advances in treatment options for diabetes outside of pregnancy, women still have a significantly increased risk of adverse obstetric outcomes including perinatal death and congenital malformation, compared to the non-diabetic population. An understanding of the physiological changes during pregnancy, management, early detection and prevention of complications and pre-pregnancy care, specific to women with pre-existing diabetes, is important in improving health outcomes in this growing group of women. This review particularly focuses on areas where there have been recent developments or controversy.

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