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Minerva Endocrinologica 2014 September;39(3):141-54

Copyright © 2014 EDIZIONI MINERVA MEDICA

language: English

Endometriosis: translation of molecular insights to management

Langan K. L. 1, Farrell M. E. 2, Keyser E. A. 3, Salyer B. A. 4, Burney R. O. 5

1 Department of Obstetrics and Gynecology, Darnall Army Medical Center, Killeen, TX, USA; 2 Department of Obstetrics and Gynecology, Naval Medical Center San Diego, San Diego, CA, USA; 3 Department of Obstetrics and Gynecology, William Beaumont Army Medical Center, El Paso, TX, USA; 4 Department of Obstetrics and Gynecology, Evans Army Community Hospital, Colorado Springs, CO, USA; 5 Departments of Obstetrics and Gynecology and Clinical Investigation, Madigan Army Medical Center, Tacoma, WA, USA


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Endometriosis is a debilitating gynecologic disorder causing pelvic pain and infertility and characterized by the implantation of endometrial tissue to extrauterine locations. Though aspects of the condition remain enigmatic, the molecular pathophysiology of endometriosis appears to be clarifying. Estrogen dependence of the disease is a sentinel endocrine feature and reduction of estrogen bioavailability is the therapeutic principle upon which traditional treatment and prevention approaches have been based. Endometriosis is a chronic inflammatory condition associated with lesional neoangiogenesis and attenuated progesterone action at the level of the endometrium. The elucidation of the molecular pathways mediating these observations has revealed new targets for directed medical and surgical treatment. This paper will review current approaches to the management of endometriosis in the context of the molecular pathophysiology.

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roburney@stanford.edu