Advanced Search

Home > Journals > Minerva Endocrinologica > Past Issues > Minerva Endocrinologica 2007 June;32(2) > Minerva Endocrinologica 2007 June;32(2):87-94



A Journal on Endocrine System Diseases

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,118

Frequency: Quarterly

ISSN 0391-1977

Online ISSN 1827-1634


Minerva Endocrinologica 2007 June;32(2):87-94


Neuroprotective effects of estrogen and selective estrogen receptor modulators begin at the plasma membrane

Sheldahl L. C., Marriott L. K., Bryant D. N., Shapiro R. A., Dorsa D. M.

Department of Physiology and Pharmacology Oregon Health and Science University Portland, OR, USA

Estrogen is neuroprotective in a large number of models in vivo and in vitro. Its application in hormone replacement therapy has proven to be more complicated, necessitating better understanding of how estrogen signals in the brain. Estrogen binds to estrogen receptors to regulate gene transcription, and activates a number of rapid signaling cascades from the plasma membrane. These rapid signaling cascades have been shown to play important roles in mediating the neuroprotective effects of estrogen. This review covers evidence that understanding and targeting the membrane effects of estrogen has emerged as an important area in the design of novel neuroprotective drugs.

language: English


top of page