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A Journal on Endocrine System Diseases

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Minerva Endocrinologica 2003 September;28(3):255-8

language: Italian

Necrotising histiocytic lymphadenitis in a patient with hypothyroidism. Aetiopatho-genesis and description of a rare clinical case

Pallotti S., Gasbarrone A., Giuliano S.


Necrotising histiocytic lymphadenitis or Kikuchi-Fujimoto's disease is a rare benign disease characterised by cervical necrotising lymphadenopathy, high temperature, asthenia with complete restitutio ad integrum of the lymphnodal stations affected. A female patient A.B., aged 36, reached our clinic at the Medical Physiopathology Department of Rome's Umberto I Polyclinic in March 2001 for an endocrinological examination. The patient reported symptoms that led us to suspect hypothyroidism, a diagnosis that was later confirmed by haematochemical examinations and treated with Eutirox 100 g. After one month the patient returned to our clinic complaining of intensive asthenia, a feeling of general malaise, lack of appetite, serotin fever and painful laterocervical lymphadenopathy. Lymphnode biopsy gave an outcome of NHL. The histological finding suggested we should treat the case with anti-inflammatory drugs and after one month the symptoms had substantially retreated. To conclude, we suppose there is a possible relationship between the viral aetiology with chronic evolution of hypothyroidism in our patient and that of NHL.

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