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A Journal on Endocrine System Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Endocrinologica 1999 June;24(2):63-8
Use of FSH in adolescents and young adults with left idiopathic varicocele, not submitted to surgery: preliminary study
Radicioni A., Schwarzenberg T. L.
Background. To study gonadal function in young patients suffering from left varicocele. Methods. Design: prospective study. Setting: university laboratory and clinical services. Patients: 20 boys (age range: 15-20 yrs; mean±DS: 17,9±1,48 yrs), affected by left idiopathic varicocele. Intervention: high purified urinary FSH s.c. (Metrodin HP 75, Ares-Serono), three times every week, for three months. Main outcome measures: seminal fluid examination before and after therapy (WHO).
Results. At the end of the study period a statistically increase of sperm density/ml (38,45¥106 vs 49,10¥106), total sperm number/ejaculate with forward motility (37,41¥106 vs 48,52¥106) and a decrease of atypical forms (54,35% vs 49,60%) has been observed; the increase of the total sperm number/ejaculate after FSH treatment greater than 50% compared with basal values allows to define 9 patients as responders.
Conclusions. In this study the FSH treatment in young people with varicocele leads to a statistically significant increase in the seminal fluid parameters and may characterize a group of patients who may have a better prognostic outcome regarding the tubular gonadal function and thus the fertility potential in adult life.