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MINERVA CHIRURGICA

A Journal on Surgery


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Minerva Chirurgica 2017 Feb 23

DOI: 10.23736/S0026-4733.17.07321-7

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Dynamic relationship between postoperative infection and CRP, IL-6 and Livin in patients with bone tumors

Ge CHEN

Department of Orthopedics, First Affiliated Hospital of South-West Medical University, Luzhou, Sichuan Province, China


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BACKGROUND: The objective of the present study was to investigate the dynamic relationship between postoperative infection and levels of CRP, IL-6, and Livin in patients with bone tumors.
METHODS: A total of 126 patients with bone tumors admitted to our hospital from November 2013 to October 2015 were randomly selected and retrospectively analyzed. According to whether postoperative infection occurred, patients were divided into the infected group (n=52) and the non-infected group (n=74). Before surgery, and on the 1st, 3rd, 5th, 7th, and 10th day after surgery, the levels of serum CRP and IL-6 of patients in both groups were compared; the relative expression levels of Livin protein of patients in both groups were measured by Western blot.
RESULTS: After surgery, the levels of CRP and IL-6 of patients in both groups at all time points were significantly higher than those before surgery and the levels of CRP and IL-6 of the infected group were significantly higher than those of the non-infected group (P<0.05). The levels of CRP and IL-6 reached a peak on the 3rd day after surgery, and CRP declined rapidly. The levels of IL-6 declined slowly. On the 10th day after surgery, the levels of IL-6 of patients in both groups were higher than those before surgery and the levels of IL-6 of patients in the infected group were higher than those of the control group (P<0.05). The levels of Livin protein in patients of both groups were not significantly different (P>0.05).
CONCLUSIONS: The increase of the levels of CRP and IL-6 are closely related to infection. Livin has no close relationship with the occurrence of infection.


KEY WORDS: Bone tumors - Postoperative infection - Livin - CRP - IL-6

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