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Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,877
Online ISSN 1827-1626
Jolanta A. DARDZIŃSKA 1, Łukasz KASKA 2, Piotr WIŚNIEWSKI 2, Ewa ALEKSANDROWICZ–WRONA 1, Sylwia MAŁGORZEWICZ 1
1 Department of Clinical Nutrition, Medical University of Gdańsk, Gdańsk, Poland; 2 Department of General, Endocrine and Transplant Surgery, Medical University of Gdańsk, Gdańsk, Poland
BACKGROUND: Mechanisms underlying the metabolic effect of surgical treatment for morbid obesity are still not clear. Furthermore, the hormonal and metabolic response to the promising and moreover less invasive modification of Roux en Y Gastric Bypass (RYGB); Mini Gastric Bypass (MGB) is poorly known. The aim of this study was to evaluate pre- and post-prandial changes in PYY and metabolic parameters in obese patients without diabetes and cardiovascular complications treated by both versions of gastric bypass.
METHODS: Venous blood for PYY and other assays was collected three months before and six months after bariatric operation (MGB and RYGB) - in the fasting state and two hours after the consumption of a standard 300 kcal-mixed meal (Nutridrink standard, Nutricia).
RESULTS: In the group of patients after MGB, both fasting and post-prandially, the elevated concentrations of the PYY has been detected. The effect of the MGB on the PYY levels did not differ from the RYGB outcomes.
CONCLUSIONS: Results of our study indicate a similar endocrine and metabolic effects of both MGB and RYGB treatments. Long-term efficacy and metabolic benefits of the MGB require further research.