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Minerva Chirurgica 2013 April;68(2):191-7

language: English

Correlation of thyroid fine-needle aspiration with final histopathology: a case series

Gürkan Dumlu E. 1, Kiyak G. 1, Bozkurt B. 1, Tokaç M. 1, Polat B. 2, Çakir B. 2, Güler G. 3, Kiliç M. 4

1 Atatürk Research and Training Hospital Department of General Surgery, Ankara, Turkey;
2 Yıldırım Beyazıt University Faculty of Medicine Department of Endocrinology, Ankara, Turkey;
3 Yıldırım Beyazıt University Faculty of Medicine Department of Pathology, Ankara, Turkey;
4 Yıldırım Beyazıt University Faculty of Medicine Department of General Surgery, Ankara, Turkey


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Aim: The aim of this study was to evaluate the correlation between preoperative thyroid fine-needle aspiration result and final histopathology in patients with thyroid nodules.
Methods: The medical records of 298 patients (mean age, 47.7±12.3 years; 79.5% females) who underwent fine-needle aspiration for thyroid nodules and who were operated and have final pathological diagnosis were retrospectively reviewed. For reporting fine-needle aspiration specimen pathology, the Bethesda thyroid fine-needle aspiration classification was used. Tyroglobulin (Tg) and anti-Tg and anti-thyroid peroxidase (anti-TPO) antibody levels were determined preoperatively.
Results: Thyroid nodules were non-diagnostic, benign or atypia (Bethesda groups 1-3) in 76.8% of patients; and follicular neoplasm, suspicious for malignancy or malignant (Bethesda groups 4-6) in 23.1% of patients. Final pathology of surgery specimen was most commonly nodular goiter (36.6%) and papillary carcinoma (35.6%). Nodular goiter was significantly more prevalent in Bethesda 1 group while papillary carcinoma was more common in Bethesda 3 group (P<0.05). Tg level is significantly higher in the nodular goiter group (90.49±126.93 ng/mL), while anti-Tg and anti-TPO levels are significantly higher in the lymphocytic thyroiditis goiter group (229.77±494.42 U/mL and 282.86±360.77 U/mL, respectively) than the other pathology groups (P<0.05 for all).
Conclusion: Papillary carcinoma is more common in Bethesda thyroid fine-needle aspiration classification 3 group. Therefore, preoperative fine-needle aspiration for thyroid nodules is predictive of final pathology and should be applied for diagnosis and follow-up.

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