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Minerva Chirurgica 2011 June;66(3):251-68

language: English

K-Ras role in lung cancer therapy

Zhang Z. 1,2, Zhou Wang 1

1 Department of Thoracic Surgery, Provincial Hospital Affiliated to , Shandong University, Jinan, China;
2 Department of Thoracic Surgery, Jinan Central hospital Affiliated to , Shandong University, Jinan, China


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The ras gene family provides a global effect on gene expression by encoding small GTP-binding proteins which act as molecular switches connecting extracellular signals with nuclear transcription factors. Mutations on the K-ras gene have been found in 20-30% of non-small-cell lung cancers and are believed to play a key role in this malignancy. The ras-signaling pathway has attracted considerable attention as a target for anticancer therapy because of its important role in carcinogenesis. This review summarizes the structure and function of K-ras, with attention to the facets of K-ras biology that relate to tumorigenesis and focuses on those that have been targeted for lung cancer therapy.

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zhangzhiping1990@sina.com