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CURRENT ISSUEMINERVA CHIRURGICA

A Journal on Surgery

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,877

Frequency: Bi-Monthly

ISSN 0026-4733

Online ISSN 1827-1626

 

Minerva Chirurgica 2008 June;63(3):249-54

    TECHNICAL NOTES

Fibrin glue to reduce seroma after axillary lymphadenectomy for breast cancer

Ruggiero R. 1, Procaccini E. 1, Gili S. 1, Cremone C. 1, Decimo G. 1, Iovino F. 1, Decimo L. 1, Sparavigna L. 1, Subitosi A. 1, Parmeggiani D. 1, Avenia N. 2

1 General and Specialistic Surgery, Second University of Naples, Naples, Italy
2 General Endocrine Surgical Unit University of Perugia, Perugia, Italy

Axillary lymphadenectomy remains an integral part of breast cancer treatment, yet seroma formation occurs in 15-85% of cases. Among the methods employed to reduce seroma magnitude and duration, fibrin glue has been proposed in numerous studies with controversial results. Sixty patients underwent quadrantectomy or mastectomy with level I/II axillary lymphadenectomy; a suction drain was fitted in all patients. Fibrin glue spray was applied to the axillary fossa in 30 patients; the other 30 patients were treated conventionally. Suction drainage was removed between postoperative days III and IV. Seroma magnitude and duration were significantly reduced (P=0.004 and 0.02, respectively), and there were fewer evacuative punctures, in patients receiving fibrin glue compared with the conventional treatment group. The authors conclude that the use of fibrin glue does not always prevent seroma formation, but does reduce seroma magnitude, duration and necessary evacuative punctures.

language: English


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