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A Journal on Surgery

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,877

Frequency: Bi-Monthly

ISSN 0026-4733

Online ISSN 1827-1626


Minerva Chirurgica 2007 June;62(3):179-86


New advances in biology and treatment of Gastrointestinal Stromal Tumours (GISTs)

Comandone A., Boglione A., Bergnolo P., Berno E.

Department of Oncology Gradenigo Hospital and Gruppo Piemontese Sarcomi, Turin, Ital

Gastrointestinal stromal tumours (GISTs) are a precise oncogenetic entity that has started the new era of targeted therapies in solid tumours. GISTs are now a model to understand the role of oncogenic kinase mutation in tumourigenesis, duplication, cell regulation, apoptosis and drug resistance. Ninety-five percent of GISTs have some activacting mutation of c-Kit or PDGFRA tyrosine kinase. The studies of the last two years have found concrete correlations between mutations and anatomical locations of GISTs, prognosis, response to therapy and resistance to therapy. Genotyping has increased of importance in the last years as a new field for translational researches. The important advan-ces made in molecular studies are now a practical tool in diagnosis and therapy of GISTs.

language: English


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