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A Journal on Surgery

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Minerva Chirurgica 2004 August;59(4):317-24

language: English, Italian

An experimental swine model of small bowel cross transplantation

Sommariva A., Behboo R., Ruffolo C., Scarpa M., Termini B., Barollo M., Ghaemian A., Carraro P., D'Amico D. F.


Aim. In this study we evaluated the possibility of performing a cross small bowel transplantation (CrSBTx) in which, at the same time, 2 pigs were both donors and later recipients of intestinal grafts. The hemodynamic and metabolic impact of this original transplantation model on the animals was determined.
Methods. Ten large White adult female pigs underwent a 2 stage procedure. The principal intraoperative hemodynamic and metabolic parameters were measured at different times during the operation. In the 3 days that followed the operation, renal function, liver and pancreatic damage were investigated.
Results. Our surgical model permits us to keep excellent hemodynamic and metabolic stability with low mortality.
Conclusion. The need of half of animals with respect to conventional models represents an ethical and economic advantage of CrSBTx and we propose it for intestinal transplant studies in large animals.

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