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A Journal on Surgery

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Minerva Chirurgica 2003 October;58(5):657-74

language: Italian

Living donor liver transplantation, adult to adult

Pinna A., Masetti M., Miller C., Dazzi A., Begliomini B., Siniscalchi A., Cautero N., Di Benedetto F., Lauro A., Girardis M., Villa E., Ramacciato G.


Aim. Since living donor liver transplantation (LDLT) can offer a viable response to the lack of transplantable cadaveric organs, our center instituted an LDLT program in 2001.
Methods. The authors report their experience with the first 35 LDLT procedures successfully completed at the Liver and Multiorgan Trans-plant Center of the University of Modena between 9 May 2001 and 21 May 2003. The case series comprised 35 patients, 7 of which received a left-half liver and 1 a left lobe.
Results. The global survival rate was 77.2% (27 out of 35 patients), with a mean follow-up period of 295 days; the survival rate at 1 year was 81%. In 4 cases (11%) retransplantation was performed. The donor demographics are described; all donors returned to their normal activities before transplantation, after a mean follow-up period of 373 days. No intraoperative complications were experienced by the donors, whereas during the postoperative period, 2 donors (5.7%) developed major complications (1 biliary fistula on the cut surface, 1 stenosis of the main bile duct).
Conclusion. Our study shows that LDLT can be safely completed in the donor, with good results achieved in the recipient as well. Underlying these results is the accurate pretransplant assessment that continued into the operation itself. Even more important was the demonstrated ability and experience of the surgical team to attain results in the donor which we believe are necessary for carrying forth a LDLT program.

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