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A Journal on Surgery

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Minerva Chirurgica 2000 November;55(11):741-4

language: Italian

Histological study of experimental splenic transplantation in rats

Gomez L., Egido R., Guarino G., Perez L., PiÒol C.


Background. The objective of this paper was to demostrate that the grafts of cervical splenic transplantation on rats using our experimental model present a normal histological appearance.
Methods. Isogenic consanguineous Lewis rats 12 weeks old and weighing 250 gr. were used. Histological findings of a group of 25 cervical splenic grafts transplanted by means of splinting vascular venous microanastomoses and a group of 25 splenic grafts autotrasplanted in the omentum were compared with a control group. The specimens were assigned according to a score of 0 to 4, following Moore's histological criteria.
Results. All grafts in transplanted and autotransplanted groups had a score of 3 or 4. Then, all splenic grafts from the transplanted group had histological findings very similar to a normal spleen. In the autotransplantation group, the percentage of grafts with a score 3 (60%) was superior to the transplantation group (46%). However, the transplantation group presented a percentage of score 4 (54%), superior to the autotransplantation group (40%).
Conclusions. In our study all grafts from the cervical spleen transplantation group had histological findings very similar to a normal spleen. The percentage of spleens with histological normality in the transplantation group was superior to the autotransplantation goup. However, there was no statistical significance.

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