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Minerva Chirurgica 2000 November;55(11):741-4

language: Italian

Histological study of experimental splenic transplantation in rats

Gomez L., Egido R., Guarino G., Perez L., PiÒol C.


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Background. The objective of this paper was to demostrate that the grafts of cervical splenic transplantation on rats using our experimental model present a normal histological appearance.
Methods. Isogenic consanguineous Lewis rats 12 weeks old and weighing 250 gr. were used. Histological findings of a group of 25 cervical splenic grafts transplanted by means of splinting vascular venous microanastomoses and a group of 25 splenic grafts autotrasplanted in the omentum were compared with a control group. The specimens were assigned according to a score of 0 to 4, following Moore's histological criteria.
Results. All grafts in transplanted and autotransplanted groups had a score of 3 or 4. Then, all splenic grafts from the transplanted group had histological findings very similar to a normal spleen. In the autotransplantation group, the percentage of grafts with a score 3 (60%) was superior to the transplantation group (46%). However, the transplantation group presented a percentage of score 4 (54%), superior to the autotransplantation group (40%).
Conclusions. In our study all grafts from the cervical spleen transplantation group had histological findings very similar to a normal spleen. The percentage of spleens with histological normality in the transplantation group was superior to the autotransplantation goup. However, there was no statistical significance.

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