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A Journal on Surgery

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Minerva Chirurgica 1999 July-August;54(7-8):537-44

language: Italian

Synthetic mesh in the surgical repair of large abdominal wall defects. An experimental study

Palmieri B., Gozzi G., Palmieri G., Marzona L.


Background. The aim of this study is to evaluate the biocompatibility of Angimesh® mesh (polypropilene) in rats, usually used to replace or to strenghten the abdominal fasciae.
Methods. We made an abdominal longitudinal incision of skin and muscles in 20 rats was carried out and two muscular semilunae removed. The incision was occluded with Angimesh® mesh fixed by ethilcyanoacrilate glue (first group of rats) or with suture stitches (second group of rats). The animals were sacrificed after 80 days and the stability of the mesh and the presence of endoperitoneal adhesion were evaluated macroscopically, and microscopically the fibrogenesis and inflammation answer.
Results. Two rats of the first group and seven of the second group died before 30 days. The mesh was more steady when fixed by suture. Adhesion in the contact sites between the mesh and the peritoneum was found. Histology did not show any inflammation reaction but showed a fibrogenic answer.
Conclusions. The cyanoacrilate non-toxicity has been confirmed also in this application. Angimesh® mesh showed good biocompatibility and resulted ideal for the synthesis of large abdominal resections.

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