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MINERVA CARDIOANGIOLOGICA

A Journal on Heart and Vascular Diseases


Official Journal of the Italian Society of Angiology and Vascular Pathology
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Minerva Cardioangiologica 2017 Mar 07

DOI: 10.23736/S0026-4725.17.04371-7

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

The role of myocardial fibrosis in determining the success rate of ablation for the treatment
of atrial fibrillation

Subothini SELVENDRAN 1, Nikhil AGGARWAL 1, Justin LI 2, Gary TSE 2, 3, 4, Vassilios S. VASSILIOU 1, 5

1 Royal Brompton Hospital and Imperial College London, UK; 2 Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, P.R. China; 3 Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, P.R. China; 4 School of Health Sciences, University of Manchester, Manchester, UK; 5 Norwich Medical School, University of East Anglia, Bob Champion Research & Education Building, James Watson Road, Norwich, UK


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Atrial fibrillation is the most common sustained cardiac arrhythmia and with an aging population its prevalence will increase. In addition to appropriate anticoagulation to reduce the thromboembolic risk, there has been an increasing need for a personalised approach in identifying which patients are likely to benefit more from atrial fibrillation ablation procedures. This review will discuss the role of myocardial fibrosis in patients with atrial fibrillation, its mechanistic role, association with biomarkers and how this could potentially be of use in the development of a risk score identifying the success of maintaining sinus rhythm following an electrophysiological ablation.


KEY WORDS: Atrial fibrillation - Ablation - Myocardial fibrosis

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v.vassiliou@rbht.nhs.uk