Home > Journals > Minerva Cardioangiologica > Past Issues > Minerva Cardioangiologica 2016 April;64(2) > Minerva Cardioangiologica 2016 April;64(2):114-20

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints
Cite this article as

MINERVA CARDIOANGIOLOGICA

A Journal on Heart and Vascular Diseases


Official Journal of the Italian Society of Angiology and Vascular Pathology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,695


eTOC

 

ORIGINAL ARTICLES  


Minerva Cardioangiologica 2016 April;64(2):114-20

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Association between 1019C/T polymorphism in the connexin 37 gene and dilated cardiomyopathy

J. TANG 1, 2, L. LI 1, L. Q. HU 2, Q. Y. CAI 2, L. CHEN 2

1 The Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Shandong University, Qilu Hospital, Chinese Ministry of Education and Chinese Ministry of Health, Jinan, Shandong, China; 2 Department of Geriatric Cardiology Provincial Hospital Affiliated to Anhui Medical University, HeFei, China


PDF  


BACKGROUND: The aim of this paper was to investigate the association between the connexin 37 (CX37) 1019C/T polymorphism and susceptibility to dilated cardiomyopathy (DCM).
METHODS: Han Chinese diagnosed with DCM between 2005 and 2013 were studied, and they were compared with a control group of 816 persons without DCM from a patient cohort from the Provincial Hospital Affiliated to Anhui Medical University, China. A total of 873 patients with DCM were included. All study and control cases were genotyped by DNA sequencing.
RESULTS: Polymorphism C1019T on the Connexin37 gene (CX37) was found in the whole population. The distribution of three genotype frequencies in both groups was in accordance with Hardy-Weinberg equilibrium. The frequency of the CX37 C allele was higher in DCM patients (57.33% vs. 42.03%, P<0.01) compared to the control group. The frequency of C carriers (CC+TC) was 80.41% in DCM patients, compared to 66.7% in controls (P<0.01). DCM risk was significantly increased in carriers of the C allele (CC+TC) than in TT homozygotes (odds ratio [OR]=2.05, 95% confidence interval [CI]: 1.65-2.56). Subsequent stratified analyses demonstrate that a significant difference exists in the frequency of C carriers between male DCM patients and controls (77.61% vs. 69.04%, P<0.01) and in female DCM patients and controls (85.62 % vs. 62.19%, P<0.01). Carriers of the C allele had higher DCM risk compared with TT homozygotes with sex differences (male: OR=1.64, 95% CI: 1.39-1.95; female: OR=2.32, 95% CI: 1.84-2.94).
CONCLUSIONS: The C allele in the CX37 gene might be associated with susceptibility to DCM in Chinese Han. Female carriers of the C allele had higher DCM risk compared with TT homozygotes than males.

top of page

Publication History

Cite this article as

Tang J, Li L, Hu LQ, Cai QY, Chen L. Association between 1019C/T polymorphism in the connexin 37 gene and dilated cardiomyopathy. Minerva Cardioangiol 2016 April;64(2):114-20. 

Corresponding author e-mail

guo13665103927@163.com