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A Journal on Heart and Vascular Diseases

Official Journal of the Italian Society of Angiology and Vascular Pathology
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Minerva Cardioangiologica 2015 December;63(6):525-31

language: English

Degesting the remodeled cardiovascular wall: role of cysteinyl cathepsins in cardiovascular disease

Song H. 1, Jiang H. 2, Nan Y. 3, Cheng X. 4

1 Department of Neurology, Yanbian University Hospital, Jilin, Yanbian, Yanji, China;
2 Department of Physiology and Pathophysiology, Yabian University Medical College, Jilin, Yanbian, Yanji, China;
3 Department of Anesthesiology, Yanbian University Hospital, Jilin, Yanbian, Yanji, China;
4 Department of Cardiology, Yanbian University Hospital, Jilin, Yanbian, Yanji, China


Cardiovascular disease (CVD) is characterized by extensive remodeling of the extracellular matrix (ECM) architecture of the cardiovascular system. Among the many extracellular proteolytic enzymes present in cardiovascular cells and inflammatory cells and involved in ECM remodeling, members of the matrix metalloproteinase family and serine protease family have received the most attention. However, recent findings from laboratory and clinical studies have indicated that lysosomal cysteinyl cathepsins also participate in pathogenesis of CVD. This review summarizes recent knowledge on discoveries regarding the relationship between cysteinly cathepsins and CVD.

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