Advanced Search

Home > Journals > Minerva Cardioangiologica > Past Issues > Minerva Cardioangiologica 2015 December;63(6) > Minerva Cardioangiologica 2015 December;63(6):525-31

ISSUES AND ARTICLES   MOST READ   eTOC

CURRENT ISSUEMINERVA CARDIOANGIOLOGICA

A Journal on Heart and Vascular Diseases

Official Journal of the Italian Society of Angiology and Vascular Pathology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,752

Frequency: Bi-Monthly

ISSN 0026-4725

Online ISSN 1827-1618

 

Minerva Cardioangiologica 2015 December;63(6):525-31

    REVIEWS

Degesting the remodeled cardiovascular wall: role of cysteinyl cathepsins in cardiovascular disease

Song H. 1, Jiang H. 2, Nan Y. 3, Cheng X. 4

1 Department of Neurology, Yanbian University Hospital, Jilin, Yanbian, Yanji, China;
2 Department of Physiology and Pathophysiology, Yabian University Medical College, Jilin, Yanbian, Yanji, China;
3 Department of Anesthesiology, Yanbian University Hospital, Jilin, Yanbian, Yanji, China;
4 Department of Cardiology, Yanbian University Hospital, Jilin, Yanbian, Yanji, China

Cardiovascular disease (CVD) is characterized by extensive remodeling of the extracellular matrix (ECM) architecture of the cardiovascular system. Among the many extracellular proteolytic enzymes present in cardiovascular cells and inflammatory cells and involved in ECM remodeling, members of the matrix metalloproteinase family and serine protease family have received the most attention. However, recent findings from laboratory and clinical studies have indicated that lysosomal cysteinyl cathepsins also participate in pathogenesis of CVD. This review summarizes recent knowledge on discoveries regarding the relationship between cysteinly cathepsins and CVD.

language: English


FULL TEXT  REPRINTS

top of page