Home > Journals > Minerva Cardioangiologica > Past Issues > Minerva Cardioangiologica 2010 October;58(5) > Minerva Cardioangiologica 2010 October;58(5):583-88

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA CARDIOANGIOLOGICA

A Journal on Heart and Vascular Diseases


Official Journal of the Italian Society of Angiology and Vascular Pathology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,752


eTOC

 

REVIEWS  INTENSIVE CARDIAC CARE - PART II


Minerva Cardioangiologica 2010 October;58(5):583-88

language: English

Treatment of coronary in-stent restenosis with a novel paclitaxel urea coated balloon

Cremers B. 1, Clever Y. 1, Schaffner S. 2, Speck U. 3, Böhm M. 1, Scheller B. 1

1 Clinic of Internal Medicine III, Saarland University Hospital, Homburg/Saar, Germany;
2 Invatec Technology Center, Frauenfeld, Switzerland;
3 Radiology, Charité, Humbold University of Berlin, Berlin, Germany


PDF  


Randomized clinical trials investigating the treatment of coronary in-stent restenosis with paclitaxel iopromide coated balloon catheters have shown favorable results. The aim of the present clinical investigation was to assess the efficacy of a novel paclitaxel urea coated angioplasty balloon in the treatment of coronary in-stent restenosis. A total of 26 restenotic bare metal stents in 23 patients with a lesion length of 22.8±11.1 mm and a reference vessel diameter of 2.64±0.31 mm were treated. Up to six months and including the six-month angiographic control, only one target lesion revascularization was necessary; in total, the rate of major adverse cardiovascular events until six-month follow-up was 4.3 %. In-stent late lumen loss was 0.07±0.37 mm, in-segment late lumen loss 0.02±0.50 mm. Binary restenosis was present in one patient (4.3%). The results of this first-in-human series with a paclitaxel urea coated balloon are comparable to paclitaxel iopromide coated balloon catheters. Randomized, controlled clinical trials are warranted to further evaluate this promising approach.

top of page

Publication History

Cite this article as

Corresponding author e-mail

bruno.scheller@uks.eu