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A Journal on Heart and Vascular Diseases

Official Journal of the Italian Society of Angiology and Vascular Pathology
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Minerva Cardioangiologica 2008 June;56(3):295-305

language: English

Predictors of restenosis after coronary artery stenting

Yoneyama K. 1, Tsuboya A. 2, Kogo M. 2, Kiuchi Y. 2, Takeyama Y. 3

1 Health Service Center Showa University, Tokyo, Japan
2 Department of Pathophysiology School of Pharmaceutical Sciences Showa University, Tokyo, Japan
3 Department of Cardiology Showa University Fujigaoka Hospital, Yokohama, Japan


Aim. The aim of this study was to analyze restenosis after percutaneous coronary intervention, factors related to restenosis after coronary artery stenting and the degree of the risk of restenosis were evaluated.
Methods. The study enrolled 181 patients (249 lesions) who underwent the first coronary artery stenting. Multivariate analysis was performed, and the restenotic index (RI) was calculated by combining the extracted predictors.
Results. Among the 181 patients (249 lesions), restenosis occurred in 89 (111 lesions) and did not occur in 92 (138 lesions). Vascular revasculation was performed in 95 restenosed target lesions in 68 patients. The mean period of follow-up angiography after the procedures was 206 days in the restenosis group and 271 days in the non-restenosis group, i.e. significantly shorter in the restenosis group. As a result of multivariate analysis, diabetes mellitus, Cr level, amount of the contrast medium used and stent diameter were selected as significant factors that independently contributed to the restenosis after coronary artery stenting. By combining these factors, the RI was calculated by the following formula for the prediction of restenosis: RI=exp (1.088¥Cr+0.909¥diabetes mellitus+0.871¥contrast medium+0.591¥stent diameter).
Conclusion. The risk of restenosis after coronary artery stenting can be predicted to an extent according to the RI devised in this study.

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