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MINERVA CARDIOANGIOLOGICA

A Journal on Heart and Vascular Diseases


Official Journal of the Italian Society of Angiology and Vascular Pathology
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Minerva Cardioangiologica 2008 February;56(1):155-66

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English

Future stent drug delivery systems

Caixeta A. 1, Abizaid A. 2, 3, Aoki J. 2, 3, Dangas G. 2, 3, Mehran R. 2, 3

1 Heart Institute, Brasilia, DF, Brazil 2 Columbia University Medical Center New York, NY, USA 3 Cardiovascular Research Foundation New York, NY, USA


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Drug-eluting stents (DES) with antiproliferative drugs attached via polymers on the stent surface have reduced in-stent restenosis and repeat revascularization compared with bare metal stent (BMS) across nearly all lesion and patient subsets. However, the small number of patients with in-stent restenosis after DES treatment still exists. Furthermore, concerns about long-term safety of DES are raised, particularly regarding the higher-than-expected late-event thrombosis. There is no doubt that the DES will continue to play a pivotal role in the treatment of coronary artery disease, yet future designs need to incorporate features that reduce thrombosis and promote endothelialization along with maintaining the efficacy. This review focuses on novel generation of DES, discussing new programs, including new antiproliferative agents, novel polymeric and non polymeric stents.

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