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A Journal on Heart and Vascular Diseases

Official Journal of the Italian Society of Angiology and Vascular Pathology
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  National Meeting of Angiology XXVIII SIAPAV National Congress
Rome, November 15-18, 2006

Minerva Cardioangiologica 2006 December;54(6):811-4


language: Italian

Dysthroidism and connective pathology

Schachter I., Antignani P. L.

UOC di Angiologia, Azienda Ospedaliera S.Giovanni-Addolorata, Roma


Aim. The aim of the study is to evaluate the degree of the relationship between dysthyroidism and connective pathology, both auto-immune diseases, presenting, sometimes, an early common symptom: the Raynaud phenomenon.
Methods. We studied 30 patients, subdivided as follows: 18 affected by mixed connective pathology, 6 by scleroderma, 2 by CREST, 4 by scleroderma and Sin. of Sjogren. We focused our attention on the chronology and the duration of the diagnosis, correlated to the laboratory parameters and the hypothesis of the pathogenetic pathway.
Results. 36.6% were positive to both the pathologies. One of the 11 patients resulted positive to hyperthyroidism and mixed connective, 10 patients resulted positive to hypothyroidism subdivided in: 6 affected by sclerodermia and 4 by sclerodermia and S. of Sjogren.
All the patients were positive to ANA, without correlation between those values and the microsomial or antithyreoglobulin antibodies: the last two were present in 33%.
The laboratory parameters indicating the inflammatory state were in the normal range, a light hypercolesterolemy was found in all patients.
Conclusion. There is a suggestive relationship between the connective pathology and dysthyroidism, therefore it can be useful to evaluate always the association of both the pathologies for future identification of the immunogenetic alteration factors, the evaluation of the composition and the turnover of the collagene, subdividing the patients in relation to the clinical and the laboratory parameters, follow up to middle and long term.

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