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A Journal on Heart and Vascular Diseases

Official Journal of the Italian Society of Angiology and Vascular Pathology
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Minerva Cardioangiologica 2006 December;54(6):725-33

language: English

Functional mitral regurgitation and chronic heart failure

Ennezat P. V. 1, Marechaux S. 1, Asseman P. 1, Lejemtel T. H. 2, Van Belle E. 1, Bauters C. 1, De Groote P. 1

1 Cardiology Hospital, Lille, France
2 Tulane Medical School, New Orleans, LA, USA


Functional mitral regurgitation (MR) frequently develops during the progression of chronic heart failure and predicts poor outcome. Impaired left ventricular (LV) function, LV remodeling associated with papillary muscle apical displacement and annular enlargement result in decreased mitral closing forces and tenting of the mitral valve at closure. Reduced closing forces and tenting both promote MR. Active myocardial ischemia, myocardial asynchronism and excessive loading conditions worsen MR at rest and during exercise. The therapeutic target in functional MR is the left ventricle and not the valve.

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