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Official Journal of the Italian Society of Angiology and Vascular Pathology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,752
Online ISSN 1827-1618
Pellicano R., Oliaro E., Berrutti M., Ponzetto A., Rizzetto M.
Gastroesophageal reflux disease (GERD) is highly prevalent in the general population.
Heartburn and acid regurgitation are considered the ''typical'' presentation of GERD, that however might represent a major pathogenic mechanism in patients with chest pain without coronary artery disease. Chest pain in this instance is often successfully treated with high-dose antisecretory drugs, but the pathogenetic mechanism remains unclear. Further research is needed to clarify the role of GERD on the pathogenesis of chest pain and to ascertain whether a medical or surgical anti-secretory treatment could represent a possible approach.
Patients with non-cardiac chest pain of unknown origin should be carefully screened for the occurrence of GERD.