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A Journal on Heart and Vascular Diseases

Official Journal of the Italian Society of Angiology and Vascular Pathology
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Minerva Cardioangiologica 1999 September;47(9):315-20

language: Italian

Effectiveness of mesoglycan topical treatment of leg ulcers in subjects with chronic venous insufficiency

La Marca G., Pumilia G., Martino A.


Background. Aim of the present comparative clinical study was to demonstrate the efficacy of the topical application of mesoglycan, a profibrinolytic agent, for healing of leg ulcers in patients with chronic venous insufficiency.
Methods. Forty patients, observed in our outpatients department, with venous leg ulcers have been randomized in two groups of twenty subjects, each treated with topical application of mesoglycan (1 or 2 vials/day) or vegetal stimulins and followed for two months, with controls after 15, 30 and 60 days.
Results. At the end of the observation period, ulcer healing rate was 95% in the mesoglycan group, while a lower healing rate was obtained in the stimulins group (80%).
Conclusions. The present study confirms previous clinical experiences with mesoglycan and suggests its application in the topical treatment of venous ulcers.

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