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MINERVA CARDIOANGIOLOGICA

A Journal on Heart and Vascular Diseases


Official Journal of the Italian Society of Angiology and Vascular Pathology
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Minerva Cardioangiologica 1999 July-August;47(7-8):269-74

language: Italian

Acute cardiotoxicity due to 5-fluorouracil: an underestimated toxicity

Bertolini A., Fiumanò M., Muffatti A., Pedroncelli S., Doria A., Codazzi G., Giustiniani S., Scarinci A., Redaelli G.


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The most common toxicity in clinical trials with 5-FU, in mono or polichemotherapy, is stomatitis, diarrhea, hand-foot syndrome. In this case report, the 5-fluorouracil (5-FU) cardiotoxicity, an uncommon 5-FU-related toxicity, has been investigated. Cardiotoxicity reports are uncommon because the problem is not well known. This study is also a review of the recent literature and it recommend to take care in prescribing chemotherapy to patients with heart disease history.

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