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A Journal on Heart and Vascular Diseases

Official Journal of the Italian Society of Angiology and Vascular Pathology
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Minerva Cardioangiologica 1999 June;47(6):223-30

language: Italian

Video capillaroscopy evaluation of efficacy Ginkgo Biloba extract with L-arginine and magnesium in the treatment of trophic lesions in patients with stage 4 peripheral arterial occlusive disease

Pepe C., Rozza A., Veronesi G.


Background and aims. This study aimed to evaluate the influence of Ginkgo-Biloba extract with arginine and magnesium used for the treatment of trophic lesions in the lower limbs caused by both diabetic and non-diabetic microangiopathy.
Methods. A comparative study was carried out in 20 patients who were divided into two groups: 10 were treated with ASA plus Ginkgo-Biloba extract with arginine and magnesium and 10 with ASA plus conventional hemorrheology. The observation time was extended to 6 months, taking into consideration patients with trophic lesions to the lower limbs suffering from diabetic and non-diabetic peripheral arterial occlusive disease. The evaluation was performed by clinical, ultrasonographic and perilesional video capillaroscopy monitoring. Ultrasonographic and video capillaroscopy instrumental methods were used because they provide a full picture of macro and microcirculatory conditions around lesions.
Results. The study showed the undoubted efficacy of Ginkgo-Biloba extract with magnesium and arginine in relation to the following points: reduced healing times for the trophic lesion compared to the control group, improved painful symptoms, increased perilesional neoangiogenesis. No significant differences were observed from a Doppler ultrasonographic point of view or with regard to the claudication free interval.
Conclusions. Ginkgo-Biloba extract with ar-ginine and magnesium can improve the dynamics of cutaneous trophism in lesions caused by diabetic and non-diabetic microangiopathy.

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