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A Journal on Heart and Vascular Diseases

Official Journal of the Italian Society of Angiology and Vascular Pathology
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Minerva Cardioangiologica 1999 April;47(4):95-120

language: Italian

Hemorheological modifications induced by heparinic therapy: capillary blood viscosity, erythrocyte deformability, aggregation index

Achilli E., Cortinovis A., Ardemagni P., Crippa A.


Background. The most important problem with which doctors have to deal every day in their practice, is occlusive vascular disease, at the basis of which there is commonly a process of thrombosis. For this reason, it is very important to define early the subjects at thrombosis risk and an appropriate therapeutic strategy.
Methods. We considered 13 inpatients at thrombosis risk, c/o sezione di Clinica Medica I, dipartimento di Medicina Interna e Terapia Medica, Università di Pavia, IRCCS Policlinico S.Matteo, and 12 healthy volunteers, between March and June 1998, evaluating age, sex, weight, diseases and ongoing therapy, hemocytological, hemocoagulational and hemorheological tests before and after heparinic therapy.
Results. General blood viscosity, measured by the rotational and double-filtration method, presented no significant changes; on the contrary, capillary blood viscosity and erythrocyte deformability, measured by our new double-filtration method, showed respectively an increase and a decrease.
Conclusions. Calcium heparin is the most frequently used antithrombotic drug in thrombotic diseases and their prevention, but its action on the hemorheological profile is not clear. This study showed that it increases erythrocyte aggregation rate and decreases erythrocyte deformability, having a negative effect on the microcirculation.

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