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A Journal on Heart and Vascular Diseases
Official Journal of the Italian Society of Angiology and Vascular Pathology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,752
Minerva Cardioangiologica 1999 April;47(4):91-4
language: English, Italian
Plasma levels of E-selectin in normolipemic and hyperlipemic arteriopathic patients
Ferlito S., Gallina M., Campo S., Finocchiaro P., Catassi S., Di Salvo M. M.
Background. The authors studied the plasmatic levels of E-selectin in a group of normolipemic and hyperlipemic arteriopathic patients.
Methods. The series consisted of 73 subjects (53 male, 20 female, age 54±9) suffering from occlusive peripheral arteriopathy; 21 subjects with total cholesterol (TC) below 200 mg/dl were considered as normolipemics (group A), 24 subjects with TC between 200 and 240 mg/dl, mild hypercholesterolemics (group B), 18 with TC above 240 mg/dl, severe hypercholesterolemics (group C); 10 subjects had high triglyceride vaules (above 200 mg/dl), (group D); 12 normal controls were also considered. For each subject the determination of the E-selectin E-plasma levels was performed with an immunoenzymatic method (kit ELISA Amersham).
Results. In group A a value of E-s (4.03±0.37 ng/ml) statistically lower (p<0.05) compared to normal controls (5.71±0.61 ng/ml) was found; in group B the E-s value (3.81±0.31 ng/ml) was slightly lower than that of group A; in group C the value of E-s was 3.53±0.23 ng/ml, statistically lower compared normal controls (p<0.01) and to group A (p<0.05); in group D the E-s value (3.24±0.23 ng/ml) was sharply reduced compared to controls (p<0.01) and to groups A-B-C (p<0.05).
Conclusions. The reduction or E-selectin, was proportional to the magnitude of total cholesterol and triglycerides; the chronicity of the vasculopathy and the dyslipidemia may be responsible for an impaired biosynthetic endothelial function.