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A Journal on Biotechnology and Molecular Biology

Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,246

Frequency: Quarterly

ISSN 1120-4826

Online ISSN 1827-160X


Minerva Biotecnologica 2014 June;26(2):93-102

MicroRNAs: from basic research to therapeutic applications 


SPR-based identification of microRNAs

Breveglieri G. 1, 2, Bianchi N. 1, Finotti A. 1, Gambari R. 1

1 Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy;
2 Biotechnology Center, University of Ferrara, Ferrara, Italy

MicroRNAs (miRNAs) are small non-coding endogenous RNAs acting as post-transcriptional regulators of gene expression in eukaryotes, that play important roles in homeostatic cell processes such as development, proliferation and apoptosis. Recently, the deregulation of miRNA levels has been linked to the pathogenesis of several human diseases, including cancer initiation and progression, making them useful as prognostic and diagnostic biomarkers. Among the novel detection strategies required to identify and quantify specific miRNAs in biological samples, ultrasensitive and specific methods based on Surface Plasmon Resonance are under development in order to overcome some pitfalls of conventional miRNA diagnostic techniques.

language: English


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