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A Journal on Biotechnology and Molecular Biology

Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,246

Frequency: Quarterly

ISSN 1120-4826

Online ISSN 1827-160X


Minerva Biotecnologica 2011 December;23(4):103-16


Molecular characterization into clinical practice: current status and future perspectives in metastatic non-small-cell lung cancer

Bonanno L. 1, Calvetti L. 2, Favaretto A. 1, Rosell R.3,4

1 Department of Medical Oncology, Istituto Oncologico Veneto, I.R.C.C.S., Padua, Italy;
2 University of Padua, Padua, Italy;
3 Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Badalona, Spain;
4 Pangaea Biotech S.L, Barcelona, Spain

Non-small-cell lung cancer (NSCLC) is a common malignant disease, characterized by extremely poor prognosis. Until recently, treatment of advanced disease was based on platinum based chemotherapy, leading to great heterogeneity in terms of effectiveness, with median overall survival in the unselected population of less than one year. However, recent knowledge about genetic alterations in subsets of NSCLC has changed the clinical approach to metastatic disease. The primary efforts focus on targeted treatments that specifically inhibit vital signaling pathways. Successful examples of this new approach are the inhibition, by treating with erlotinib and gefitinib, of the epidermal growth factor receptor (EGFR) pathway in patients with EGFR mutations and the clinical development of crizotinib, effective in lung cancer harboring ALK rearrangements. Similarly, biological study concerning other molecular alterations characterizing specific subgroups of lung adenocarcinomas is likely to find clinical application soon. Genetic alterations in squamous cell carcinomas are less studied, but recent data suggest that their study could help in improving treatment also in this context. Molecular characterization can also be useful in improving chemotherapy efficacy and reducing toxicity by addressing the selection of chemoregemines.

language: English


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