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  MICROARRAY MEETING 2002: NEW DEVELOPMENTS IN MUTATION DETECTION AND GENE EXPRESSION
Segrate, MI (Italy), April 12, 2002


Minerva Biotecnologica 2002 December;14(3-4):291-304

language: English

Mak­ing ­sense of ­whole ­genome expres­sion ­data. Micro­ar­ray data­bas­es and ­tools for inte­grat­ing whole-­genome expres­sion ­results ­into cel­lu­lar net­works

Cavalieri D. 1, De Filippo C. 2, Grosu P. 1, Biggeri A. 3

1 ­Bauer Cen­ter for Genom­ic ­Research, Har­vard Uni­ver­sity, Cam­bridge MA (USA);
2 Depart­ment of Phar­ma­col­o­gy, Uni­ver­sity of Flor­ence, Flor­ence, Ita­ly;
3 Depart­ment of Sta­tis­tics, Uni­ver­sity of Flor­ence, Flor­ence, Ita­ly


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Micro­ar­rays are gen­er­at­ing a mas­sive ­amount of ­data describ­ing ­cell func­tion; clas­si­fy­ing ­these ­data and inte­grat­ing the infor­ma­tion pro­duced ­with pre­vi­ous­ly accu­mu­lat­ed bio­log­i­cal infor­ma­tion. There­fore the ­main ­efforts to ­make ­sense of micro­ar­ray ­data are direct­ed to the con­struc­tion of data­bas­es of micro­ar­ray experi­ments, in ­order to inte­grate the infor­ma­tion on the expres­sion of a ­group of ­genes ­with the avail­able bio­logi­cal infor­ma­tion. The aim of ­this ­review is to ana­lyse crit­i­cal­ly the ­most impor­tant ­issues in build­ing data­bas­es of micro­ar­ray experi­ments and to dis­cuss the poten­tials of a path­way-­based ­approach to the anal­y­sis of micro­ar­ray ­data.

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