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CURRENT ISSUEMINERVA BIOTECNOLOGICA

A Journal on Biotechnology and Molecular Biology

Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,246

Frequency: Quarterly

ISSN 1120-4826

Online ISSN 1827-160X

 

Minerva Biotecnologica 2002 June;14(2):149-53

7th INTERNATIONAL CONFERENCE ON TRANSGLUTAMINASES AND PROTEIN CROSSLINKING REACTIONS
Ferrara (Italy), September 14-17, 2002 

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Trans­glu­tam­i­nase sub­strates: ­from ­test ­tube experi­ments to liv­ing ­cells and tis­sues

Csosz E., Keresztessy Z., Fesus L.

Depart­ment of Bio­chem­is­try and Molec­u­lar Biol­o­gy, Uni­ver­sity of Debre­cen, Debre­cen, Hun­gary

The num­ber of ­known trans­glu­tam­i­nase sub­strates rap­id­ly increas­es. ­Although in ­many cas­es the trans­glu­tam­i­nase-cat­a­lyzed mod­ifi­ca­tion has ­been dem­on­strat­ed in ­test ­tube experi­ments, ­more and ­more of ­these ­data are con­firmed in ­intact ­cells and tis­sues. The func­tion­al require­ments of ­being opti­mal glu­ta­myl or ­lysine ­donor pro­teins ­have not ­been com­plete­ly clar­i­fied. Con­sid­er­ing the num­ber of trans­glu­ta­mi­nas­es and ­that we are ­still at the ear­ly ­phase of pen­e­trat­ing liv­ing (par­tic­u­lar­ly intra­cel­lu­lar) ­systems to ­detect trans­glu­tam­i­nase-cat­a­lyzed mod­ifi­ca­tions, one may pre­sume the exis­tence of a ­large ­amount of ­still ­unknown sub­strate pro­teins. Learn­ing ­what ­these pro­teins are ­will ­shed new ­light on the sig­nif­i­cance of trans­glu­ta­mi­nas­es in liv­ing ­systems.

language: English


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