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Minerva Biotecnologica 2002 June;14(2):143-8

Copyright © 2003 EDIZIONI MINERVA MEDICA

language: English

The biotechnological applications of transglutaminases

Collighan R., Cortez J., Griffin M.

Department of Life Sciences, The Nottingham Trent University, Nottingham, UK


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Trans­glu­ta­mi­nas­es cat­a­lyse a ­diverse ­range of reac­tions lead­ing to the mod­ifi­ca­tion of pro­teins and pep­tides ­such ­that ­their phys­i­cal, chem­i­cal and bio­log­i­cal prop­er­ties ­become ­changed. ­They are ­found in ­many dif­fer­ent liv­ing organ­isms and as a con­se­quence dis­play sub­tle dif­fer­enc­es in ­their bio­chem­i­cal and phys­i­cal prop­er­ties. It is there­fore not sur­pris­ing ­that ­this ­group of ­enzymes ­have ­been exploit­ed as ­applied bio­cat­a­lysts in a ­wide ­range of com­mer­cial sec­tors var­y­ing ­from the tex­tile indus­try to the high­ly lucra­tive cos­met­ic indus­try. In addi­tion the path­o­phy­sio­log­i­cal impor­tance of ­this ­group of ­enzymes has ­increased sig­nif­i­cant­ly ­over the ­last ­decade ­with ­their involve­ment not­ed in a num­ber of ­human dis­eas­es. As a con­se­quence ­their iden­tifi­ca­tion as ther­a­peu­tic tar­gets or as mon­i­tor­ing ­aids for a ­range of dif­fer­ent dis­eas­es has ­caused sig­nif­i­cant inter­est ­from the diag­nos­tics and phar­ma­ceu­ti­cal indus­tries. ­This ­review ­describes ­some of the cur­rent appli­ca­tions of trans­glu­ta­mi­nas­es togeth­er ­with ­their poten­tial stra­te­gic impor­tance and ­future ­uses.

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