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Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,246
Online ISSN 1827-160X
Cortesi R. 1, Esposito E. 1, Cantelli D. 1, Nastruzzi C. 2
1 Dipartimento di Scienze Farmaceutiche, Università degli Studi di Ferrara, Ferrara, Italy;
2 Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Perugia, Italy
This paper describes the production and characterization of biodegradable microparticles containing glucosinolate hydrolysis products, designed for enteric delivery. Hydroxy propyl methyl cellulose phthalate (HPMCP) microparticles were produced by a double emulsion process using as external phase 0.1% polyvinyl alcohol solution at pH 3.5. Microparticle morphology was characterized by optical and electron microscopy. The release kinetics of the drugs from microspheres was determined using a dialysis method. The double emulsion method here described allows the production of microparticles with high encapsulation efficiency and appropriate dimensional and morphological characteristics for oral administration. Release profile data indicate that the encapsulated drug is released from microparticles with a rate adequate to a sustained enteric delivery.