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Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,246
Online ISSN 1827-160X
Klein C. T. 1, Viernstein H. 2, Wolschann P. 1
1 Institut für Theoretische Chemie und Molekulare Strukturbiologie, Wien, Austria;
2 Institut für Pharmazeutische Technologie, Wien, Austria
Inclusion of guest molecules into the hydrophobic cavity of various cyclodextrins changes the properties of these guest molecules, which can be used for a broad variety of applications. Prediction models obtained from QSAR studies lead to a better understanding of the inclusion mechanism. A special feature of such complexation is the enthalpy-entropy compensation and pronounced solubility enhancements, which are used for better bioavailabilty of drugs and, in the case of biocides for a reduction of the biologically active compounds by equal activity.