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CURRENT ISSUEMINERVA BIOTECNOLOGICA

A Journal on Biotechnology and Molecular Biology

Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,246

Frequency: Quarterly

ISSN 1120-4826

Online ISSN 1827-160X

 

Minerva Biotecnologica 2000 December;12(4):287-92

BIOENCAPSULATION 

Inclusion com­plex­a­tion ­with cyclo­dex­trins

Klein C. T. 1, Viernstein H. 2, Wolschann P. 1

1 Institut für Theoretische Chemie und Molekulare Strukturbiologie, Wien, Austria;
2 Institut für Pharmazeutische Technologie, Wien, Austria

Inclusion of ­guest mole­cules ­into the hydro­pho­bic cav­ity of var­i­ous cyclo­dex­trins chang­es the prop­er­ties of ­these ­guest mole­cules, ­which can be ­used for a ­broad varie­ty of appli­ca­tions. Prediction mod­els ­obtained ­from ­QSAR stud­ies ­lead to a bet­ter under­stand­ing of the inclu­sion mech­a­nism. A spe­cial fea­ture of ­such com­plex­a­tion is the enthal­py-entro­py com­pen­sa­tion and pro­nounced sol­u­bil­ity enhance­ments, ­which are ­used for bet­ter bio­avai­la­bil­ty of ­drugs and, in the ­case of bio­cides for a reduc­tion of the bio­log­i­cal­ly ­active com­pounds by ­equal activ­ity.

language: English


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