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Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,246
Online ISSN 1827-160X
Semino C. 1, Ferlazzo G. 1, Ratto G. B. 2, Melioli G. 1
1 Laboratorio di Immunoterapia Cellulare, Istituto Nazionale per la Ricerca sul Cancro;
2 Cattedra di Chirurgia Toracica, Università degli Studi di Genova, Genova
Adoptive immunotherapy (AI) of cancer, based upon injection of in vitro manipulated autologous lymphocytes is still in an experimental phase. Based on strong experimental and pre-clinical rationale, our group started different clinical trials of AI in early 1990, and a number of patients with solid tumors (melanoma, kidney carcinoma, non-small-cell lung cancer, mesothelioma, neoplastic pleural effusion, and liver cancer) were treated with either locoregional or systemic adoptive immunotherapy using both LAK and TIL cells in combination with s.c. rIL-2. The surgery/AI combination resulted in good clinical results, characterized by enhanced survival and long lasting disease free periods in a significant number of patients. Nevertheless, at present, new preclinical evidences and strategies are needed to enhance the efficacy of the adoptive immunotherapy approach of solid tumor treatment.