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  TUMOR IMMUNOLOGY


Minerva Biotecnologica 1999 December;11(4):243-53

language: English

Tumor-anti­gens rec­og­nised by T lym­pho­cytes

Traversari C.

Can­cer Immu­no­ther­a­py and ­Gene Ther­a­py Pro­gram DIB­IT, H S. Raf­faele, ­Milan, Ita­ly


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A num­ber of stud­ies ­have dem­on­strat­ed ­that cyto­lyt­ic T lym­pho­cytes (­CTLs) spe­cif­i­cal­ly rec­og­nis­ing autol­o­gous ­tumor ­cells, can be iso­lat­ed ­from periph­er­al ­blood (PBLs) and ­tumor infil­trat­ing-lym­pho­cytes (­TILs) of can­cer ­patients. The in ­vivo ­role of ­such ­tumor-spe­cif­ic effec­tors has ­been sug­gest­ed by ­results ­from ­both adop­tive immu­no­ther­a­py and ­active vac­ci­na­tion ­based clin­i­cal ­trials. ­These obser­va­tions jus­ti­fy the exten­sive ongo­ing ­effort direct­ed ­towards the char­ac­ter­isa­tion of the molec­u­lar ­nature of ­tumor asso­ciat­ed anti­gens (­TAAs) rec­og­nised by T ­cells. Accord­ing to the pat­tern of expres­sion in neo­plas­tic and nor­mal tis­sues, ­these anti­gens can be clas­si­fied ­into sev­er­al class­es, ­which ­have dif­fer­ent ­degrees of ­tumor spec­i­fic­ity and clin­i­cal rel­e­vance. A ­large ­array of ­TAAs ­have ­been iden­ti­fied ­from mel­a­no­ma ­cells, how­ev­er, anti­gens result­ing ­from ­point muta­tions ­have recent­ly ­been ­found ­that are rec­og­nised by autol­o­gous T lym­pho­cytes in ­renal, ­head and ­neck, and blad­der car­ci­no­mas. ­This sug­gests ­that “immu­nog­e­nic­ity” is not a spe­cif­ic fea­ture restrict­ed to mel­a­no­ma ­cells. The iden­tifi­ca­tion of ­human ­tumor rejec­tion anti­gens ­opens new pos­sibil­ities for system­at­ic approach­es to the spe­cif­ic ­immune ther­a­py of can­cer. ­This ­review sum­mar­is­es the cur­rent knowl­edge of ­human tis­sue-spe­cif­ic ­TAAs rec­og­nised by T ­cells.

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