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CURRENT ISSUEMINERVA BIOTECNOLOGICA

A Journal on Biotechnology and Molecular Biology


Indexed/Abstracted in: EMBASE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Biotecnologica 1999 June;11(2):113-27

FLOW CYTOMETRY IN IMMUNOLOGY AND HEMATOLOGY 

Mor­pho­log­ical and func­tional anal­ysis of apop­totic ­cells by ­flow cytom­etry

Mannucci R., Nicoletti I.

­Image Anal­ysis Labor­a­tory, Depart­ment of Clin­ical and Experi­mental Med­i­cine, Sec­tion of ­Internal Med­i­cine and ­Oncology, ­Perugia Uni­ver­sity Med­ical ­School, ­Perugia, ­Italy

Apop­tosis is a ­strictly reg­u­lated pro­cess for the ­removal of unnec­es­sary, ­aged or dam­aged ­cells and an alter­a­tion in the con­trol of apop­totic ­cell ­death can ­entail ­cancer, auto­im­mune dis­eases, ­immune defi­ciency and degen­er­a­tive dis­or­ders. ­This ­article ­briefly ­reviews the ­main mor­pho­log­ical and bio­chem­ical ­aspects of apop­totic ­cell ­death and ­describes sev­eral ­flow cytom­etry ­methods ­which can be ­used to ­follow ­changes ­during the apop­totic cas­cade and to quan­tify the ­number of apop­totic ­cells.

language: English


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