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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care
Minerva Anestesiologica 2016 Jun 17
Biological markers of injury-induced immunosuppression
Christelle ROUGET 1-3, Thibaut GIRARDOT 1-3, Julien TEXTORIS 1-3, Guillaume MONNERET 1, 2, 4, Thomas RIMMELÉ 1-3, Fabienne VENET 1, 2, 4 ✉
1 BioMérieux, Joint Research Unit, Hospices Civils de Lyon-BioMérieux, Hôpital Edouard Herriot, Lyon, France; 2 EAM Pathophysiology of Injury-Induced Immunosuppression, UCBL1-HCL-BioMérieux, Lyon, France; 3 Anesthesiology and Intensive care department, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France; 4 Immunology Laboratory, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France
Severe injuries such as severe sepsis, burn, trauma and major surgery lead to an overlapping development of pro- and anti- inflammatory responses. It is now well established that these injuries are associated with the secondary development of immune suppression, which results in significant morbidity and mortality. Recent data suggest that immunostimulatory drugs might prevent these complications. However, intensive care patients are heterogeneous, making patient stratification essential for a targeted treatment. In the present review, we discuss potential biomarkers of injury-induced immunoparalysis, mainly focusing on these that have been associated with poor outcome in various clinical settings. We namely present clinical data on monocyte human leukocyte antigen DR, lymphopenia, PD-1/PD-L1 and transcriptomic approach.