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CURRENT ISSUEMINERVA ANESTESIOLOGICA

A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,036

Frequency: Monthly

ISSN 0375-9393

Online ISSN 1827-1596

 

Minerva Anestesiologica 2016 Apr 05

The risk of infusing gelatin? Die-hard misconceptions and forgotten (or ignored) truths

Antonio PISANO 1, Giovanni LANDONI 2, 3, Rinaldo BELLOMO 4, 5

1 Cardiac Anesthesia and Intensive Care Unit, A.O.R.N. “Dei Colli”, Monaldi Hospital, Naples, Italy; 2 Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; 3 Vita-Salute San Raffaele University, Milan, Italy; 4 Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia; 5 Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia

Fluid therapy is considered a cornerstone of perioperative and critical care medicine. However, the type of fluids used varies widely among different countries. Synthetic colloids may negatively affect coagulation and are potentially nephrotoxic. “Modern” hydroxyethyl starches (HES) were widely used until recently when their association to mortality and renal replacement therapy risk among critically ill patients brought to restriction by the European Medicines Agency in 2013. Since synthetic colloids are traditionally thought to be much more effective as volume expanders than crystalloids (although their efficacy is probably largely overrated), there is concern that physicians, practically deprived of HES, could be tempted to rely again on “old” gelatins. The aim of this contribution is to warn clinicians that gelatins share all potential adverse effects of other synthetic colloids, and are possibly even more nephrotoxic than HES. Moreover, gelatins have no beneficial effects on outcomes as compared with crystalloids (on the contrary, they might even increase mortality), and are also more expensive. Accordingly, a “return” to gelatins should be strongly discouraged.

language: English


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