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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
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Minerva Anestesiologica 2015 November;81(11):1244-61

language: English

Complications of immunosuppressive agents therapy in transplant patients

Reske A. P. 1, Reske A. W. 2, Metze M. 3

1 Fachkrankenhaus Coswig GmbH, Division of Anesthesiology and Intensive Care Medicine, Coswig, Germany;
2 Department of Anesthesiology and Intensive Care Medicine, University Hospital Leipzig, Leipzig, Germany;
3 Division of Cardiology and Angiology, Department of Internal Medicine, Neurology and Dermatology, University Hospital Leipzig, Leipzig, Germany


Solid organ transplantation remains the gold standard for the treatment of end-stage organ dysfunction and saves thousands of lives. Besides the progress of surgery, advances in understanding transplant physiology, immunology and the development of immunosuppressive drugs lead to improved short- and long-term survival. Transplantation is offered to an increasing number of patients with higher age and comorbidities. Approximately one third of organ recipients require hospital readmission after transplantation because of a multitude of clinical problems related to immunosuppressive therapy. We review the current knowledge on typical complications associated with immunosuppressants with emphasis on the intensivist’s perspective.

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