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Online ISSN 1827-1596
Zandstra D. F. 1, Van Saene H. K. F. 2
1 Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands;
2 Department of Clinical Microbiology and Infection Control, Royal Liverpool Children’s NHS, Trust of Alderhey, Liverpool, UK
Selective decontamination of the digestive tract (SDD) evolved into evidence-based medicine as a tool to prevent infections in critically ill patients. It significantly reduces mortality, pneumonia, bloodstream infections and the onset of resistance if the full four-component regimen is used. The use of only oral decontamination may reduce the incidence of pneumonia, but it has no significant impact on mortality. Moreover, the full SDD protocol significantly reduces the fecal carriage of multiresistant aerobic Gram-negative bacteria, whereas oral decontamination only is associated with increased carriage of multiresistant aerobic Gram-negative bacilli.