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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,036

Frequency: Monthly

ISSN 0375-9393

Online ISSN 1827-1596


Minerva Anestesiologica 2011 February;77(2):142-6


Isoflurane suppresses central cardiac parasympathetic activity in rats: a pilot study

Toader E., Cividjian A., Quintin L.

Physiology (CNRS UMR 5123), University of Lyon, Lyon, France

BACKGROUND: Intraoperative circulatory stability is a function of both cardiac parasympathetic activity and cardiac and vascular sympathetic activity; however, cardiac parasympathetic activity is rarely considered. This experiment addresses the effect of isoflurane on central cardiac parasympathetic control, i.e., cardiac vagal motoneurons (CVM), which are located in the nucleus ambiguous of the brain stem and project to the sinus node.
METHODS: In urethane-anesthetized rats, the single unit activity of CVM, antidromically identified from the craniovagal cardiac branch, was observed following the introduction of isoflurane. Isoflurane was introduced slowly over 10 minutes to achieve 2% end tidal CO2 (ETCO2)
RESULTS: Following the introduction of isoflurane (2% ETCO2), all CVM were almost entirely silenced (N=6 cells in 6 different rats, 1.9 ±2.4 vs. 0.2 ±0.3 Hz, P<0.05).
CONCLUSION: The data obtained with antidromically identified cardiac vagal motoneurons confirm data obtained previously with whole vagal nerve recordings. The authors speculate on how the blunting of the cardiac parasympathetic activity by isoflurane that was observed in rats may impact intraoperative circulatory stability in humans.

language: English


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