Advanced Search

Home > Journals > Minerva Anestesiologica > Past Issues > Minerva Anestesiologica 2010 October;76(10) > Minerva Anestesiologica 2010 October;76(10):860-4

ISSUES AND ARTICLES   MOST READ   eTOC

CURRENT ISSUEMINERVA ANESTESIOLOGICA

A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,036

 

Minerva Anestesiologica 2010 October;76(10):860-4

 POINT OF VIEW

Genetics of acute lung injury: past, present and future

Flores C. 1,2, Pino-Yanes M. M. 1,2, Casula M. 1,3, Villar J. 1,3,4

1 CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Spain;
2 Research Unit, Hospital Universitario NS de Candelaria, Tenerife, Spain;
3 Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Research Unit, Dr. Negrin University Hospital, Las Palmas de Gran Canaria, Spain;
4 Associate Scientist, Keenan Research Center, St. Michael´s Hospital, Toronto, Canada

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are major health problems worldwide. Critical care physicians have long recognized that there are patients who progress poorly despite therapy while others do unexpectedly better than it might be predicted. It is now well accepted that these responses might be related to variations in the genome. However, little is known about the genes that are responsible for susceptibility and outcome in ALI and ARDS. The search for genetic variants determining susceptibility and predicting outcome is still a developing field. The identification of important associations between genotype and clinical outcomes will have an impact on the development of more efficient genotype- or phenotype-guided therapies for patients with ALI/ARDS. Using this point of view, we will discuss some of the advances in genetic association studies in relation to the occurrence and severity of ALI/ARDS. In addition, we will also discuss the strategic and medical implications of using genetic testing to detect or predict the occurrence and prognosis of ALI/ARDS.

language: English


FULL TEXT  REPRINTS

top of page