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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care
Minerva Anestesiologica 2010 February;76(2):115-9
The pharmacodynamic effects of rocuronium during general anesthesia in patients with type 2 diabetes mellitus
Alper I., Ulukaya S., Makay O., Balcioglu T. ✉
Department of Anesthesiology and Reanimation, Ege University School of Medicine, Izmir, Turkey
AIM. The aim of this prospective study was to investigate whether the neuromuscular response to rocuronium is affected by the presence of type 2 diabetes mellitus.
METHODS: Neuromuscular functions were measured after the administration of 0.6 mg/kg rocuronium with train-of-four stimulations in patients with type 2 diabetes mellitus (DM, N=14) and without diabetes mellitus (control, N=14) during isoflurane based general anesthesia. The onset time, clinical duration and recovery index of rocuronium were compared in the two groups.
RESULTS: The mean onset time (136 ± 40 vs 118 ± 20 s), clinical duration (51 ± 11 vs 48 ± 11 min) and recovery index (6.0 ± 2.5 vs 5.9 ± 1.4 min) of the neuromuscular block were not significantly different between the DM and control groups, respectively (p>0.05).
CONCLUSIONS: The present study has proven that the rocuronium-induced neuromuscular block was not affected in patients with type 2 diabetes mellitus during isoflurane based general anesthesia.