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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
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Minerva Anestesiologica 2008 January-February;74(1-2):47-9

language: English

Colistin in combination with rifampin and imipenem for treating a blaVIM-1 metallo-β-lactamase-producing Enterobacter cloacae disseminated infection in a liver transplant patient

Tascini C. 1, Urbani L. 2, Biancofiore G. 3, Rossolini G. M. 4, Leonildi A. 1, Gemignani G. 1, Bindi M. L. 3, Mugnaioli C. 4, Filipponi F. 2, Menichetti F. 1

1 Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy;
2 Liver Transplant Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy;
3 Liver Transplant Intensive Care Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy;
4 Section of Microbiology, Department of Molecular Biology, University of Siena, Siena, Italy


A case of blaVIM-1 producing E. cloacae disseminated infection in a patient submitted to orthotopic liver transplantation is described. Synergism between colistin, rifampin and imipenem was studied in vitro and this combination of three drugs was used to treat E. cloacae infection. The synergistic activity of this combination was demonstrated showing an increased activity of the serum bactericidal activity in comparison with the bactericidal activity of the serum taken during the previous therapy.

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