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Online ISSN 1827-1596
Tascini C. 1, Urbani L. 2, Biancofiore G. 3, Rossolini G. M. 4, Leonildi A. 1, Gemignani G. 1, Bindi M. L. 3, Mugnaioli C. 4, Filipponi F. 2, Menichetti F. 1
1 Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy;
2 Liver Transplant Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy;
3 Liver Transplant Intensive Care Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy;
4 Section of Microbiology, Department of Molecular Biology, University of Siena, Siena, Italy
A case of blaVIM-1 producing E. cloacae disseminated infection in a patient submitted to orthotopic liver transplantation is described. Synergism between colistin, rifampin and imipenem was studied in vitro and this combination of three drugs was used to treat E. cloacae infection. The synergistic activity of this combination was demonstrated showing an increased activity of the serum bactericidal activity in comparison with the bactericidal activity of the serum taken during the previous therapy.