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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care
Minerva Anestesiologica 2008 January-February;74(1-2):41-5
Serotonin syndrome caused by olanzapine and clomipramine
Verre M., Bossio F., Mammone A., Piccirillo M., Tancioni F., Tortorella V., Varano M.
Anaesthesiology and Intensive Care Unit, S. Giovanni di Dio Hospital, Crotone, Italy
We describe a case of severe serotonin syndrome. The patient was simultaneously taking the atypical antidepressant olanzapine and a tricyclical antidepressant, clomipramine. Symptoms included altered mental state resulting in coma, myoclonus, hyperreflexia, diaphoresis, diarrhoea, disorientation and fever. After suspension of antidepressant drugs, intensive symptomatic treatment and administration of biperiden and cyproheptadine, the patient’s condition improved.