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CURRENT ISSUEMINERVA ANESTESIOLOGICA

A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,134

Frequency: Monthly

ISSN 0375-9393

Online ISSN 1827-1596

Minerva Anestesiologica 2008 January-February;74(1-2):41-5

 

    CASE REPORTS

Serotonin syndrome caused by olanzapine and clomipramine

Verre M., Bossio F., Mammone A., Piccirillo M., Tancioni F., Tortorella V., Varano M.

Anaesthesiology and Intensive Care Unit, S. Giovanni di Dio Hospital, Crotone, Italy

We describe a case of severe serotonin syndrome. The patient was simultaneously taking the atypical antidepressant olanzapine and a tricyclical antidepressant, clomipramine. Symptoms included altered mental state resulting in coma, myoclonus, hyperreflexia, diaphoresis, diarrhoea, disorientation and fever. After suspension of antidepressant drugs, intensive symptomatic treatment and administration of biperiden and cyproheptadine, the patient’s condition improved.

language: English


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