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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care
Minerva Anestesiologica 2007 June;73(6):343-6
Postoperative vomiting reduction after laparoscopic cholecystectomy with single dose of dexamethasone
Bianchin A. 1, De Luca A. 2, Caminiti A. 2
1 Anesthesia Department, ASL 8 Asolo, G. Carretta City Hospital, Montebelluna, Treviso, Italy;
2 General and Endoscopic Surgery Unit, ASL 8 Asolo, G. Carretta City Hospital, Montebelluna, Treviso, Italy
Aim. The incidence of postoperative nausea and vomiting (PONV) is high after laparoscopic surgery. A number of drugs have been used for prevention; in some studies a single dexamethasone dose before induction of anaesthesia has been effective.
Methods. To test the effectiveness of this therapy, we recruited 80 patients in a double-blind placebo-controlled study (dexamethasone 8 mg or placebo) scheduled for laparoscopic cholecystectomy. We measured nausea, vomiting, postoperative pain and length of stay.
Results. Patients who received preoperative dexamethasone had a reduction of PONV, but experienced the same degree of postoperative pain and remained in the hospital for the same duration. No apparent side effects were observed.
Conclusion. Although only a small number of patients were tested, we confirm the efficacy of dexamethasone therapy for reduction of PONV. We suggest routine use of a single dose of dexamethasone for the prevention of PONV in laparoscopic cholecystectomy.