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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,036

Frequency: Monthly

ISSN 0375-9393

Online ISSN 1827-1596


Minerva Anestesiologica 2007 January-February;73(1-2):57-64



One-day surgery for acquired forefoot deformity: sciatic nerve blockade with mepivacaine vs mepivacaine+ropivacaine. A prospective, randomized study

Bugamelli S. 1, Zangheri E. 2, Montebugnoli M. 3, Borghi B. 4, Ricci A. 1, De Simone N. 1, Bonfatti M. 1, Elmar K. 1, Luppi M. 5, Pignotti E. 6

1 Department of Anesthesiology and Intensive Care IRCCS Istituti Ortopedici Rizzoli, Bologna, Italy
2 Department of Anesthesiology University of Bologna, Bologna, Italy
3 Department of One Day Surgery IRCCS Istituti Ortopedici Rizzoli, Bologna, Italy
4 Department of Anesthesiologic Research IRCCS Istituti Ortopedici Rizzoli, Bologna, Italy
5 Service of Hospital Pharmacy IRCCS Istituti Ortopedici Rizzoli, Bologna, Italy
6 Task Force of Statistical Analysis IRCCS Istituti Ortopedici Rizzoli Bologna, Italy

Aim. The aim of the study was to determine the doses of ropivacaine combined with mepivacaine for sciatic nerve blockade to enable the extension of analgesia without prolonged motor blockade, for the management of very painful operations in one-day surgery.
Methods. After obtaining approval by the ethics committee and written informed consent, we recruited 30 ASA I-III patients undergoing corrective orthopedic surgery of the forefoot in one-day surgery with sciatic nerve blockade. The patients were randomly divided into 3 groups: one control group, treated by 1.5% mepivacaine (300 mg), and two groups differentiated by the dose of 0.5% ropivacaine (25 and 40 mg) used in combination with 1.5% mepivacaine (225 mg). The offset data of the blockade were obtained by a self-assessment form filled in by the patients, and a direct check on discharge by a blinded observer.
Results. There was no significant difference in the duration of the blockade among the 3 groups; the extension of analgesia was significant (P<0.003) in the group treated by mepivacaine+ropivacaine 40 mg (mean 477±255 min).
Conclusion. Adequate doses of ropivacaine added to mepivacaine for peripheral blockade produce and increase the duration of analgesia without influencing the criteria for discharge after Day Surgery.

language: English, Italian


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